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What do paradigm-shifting scientists have in common? The first in a series.

To do breakthrough science, you need passion, a supportive institution and mentor, and a suitable problem.

What are the best strategies for funding high-risk, high-reward research?

Is it a good idea to propose a safe research project to NIH or NSF, then use the money for riskier work?

The deeper your idea cuts into the heart of a field, the more your peers are likely to challenge you, and only time will reveal whether your work is transformative, incremental, or wrong.