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Authors of ambitious proposals often find their work dismissed by reviewers who use that very word--ambitious--as a criticism.
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If you don't have a pathway award or a similar fellowship, you'll probably be competing for the positions left over once all the award winners have been placed.
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Once a program makes the transition to electronic submission, paper proposals will no longer be accepted.
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Funding for Greece ... Foreign postdocs in America
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The proposals that are easiest to score well--those with the best preliminary data and the most carefully considered methods and well-crafted scientific objectives--come from the most experienced investigators and, indeed, from long-established projects.
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There's no excuse for submitting a grant proposal without meticulously reviewing all the information about the program, including the fine print and recent changes, and talking to the program officer.
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If you wish to win an NRSA, you need to become a trainee again, and that means doing something new.
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Even the best review processes have a large stochastic element, so the more often you play, the more likely you are to win.
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"I'm kind of compelled to respond the same way even when I think the reviewer is a stupid jerk with no imagination and too much free time." --Anonymous
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Your application should state clear scientific objectives and have a clear and specific research plan. Pay close attention to the writing; make sure it is clear, concise, and correct.